Renal Adenocarcinoma Presenting as a Spontaneus Perirenal Hematoma in a Patient on Warfarin Therapy – Case Report and Literature Review

Miroslav Tomić, Monika Ulamec, Davor Trnski, Jordan Dimanovski, Marija Spajić, Davor Tomas, Božo Krušlin, Borislav Spajić


 We are presenting a rare case of a spontaneous extensive perirenal hematoma caused by ruptured renal adenocarcinoma in a patient who was on warfarin therapy because she had atrial fibrillation and three myocardial infarctions. A 77-year-old woman was admitted to our department with acute right flank pain and hemorrhagic shock. The anamnestic data revealed no trauma and hematuria. Abdominal ultrasonography and computed tomography scan showed large retroperitoneal hematoma. The patient underwent urgent surgery and radical nephrectomy was performed. A large retroperitoneal hematoma was found originating from a ruptured renal neoplasm in the upper pole of the right kidney.  The pathohistological diagnosis was chromophobe renal cell carcinoma. The clinical, diagnostic and therapeutic peculiarities of this rare condition are presented, along with the literature review on the topic.


chromophobe renal cell carcinoma, renal neoplasm, warfarin therapy, retroperitoneal hematoma, spontaneous rupture

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