Periodontal Disease Increases Risk for Chronic Obstructive Pulmonary Disease

Karla Ledić, Sonja Marinković, Ivan Puhar, Stjepan Špalj, Sanja Popović-Grle, Marija Ivić-Kardum, Miroslav Samaržija, Darije Plančak


The aim of this study was to explore whether a periodontal disease could be a risk indicator for a chronic obstructive pulmonary disease (COPD). The examined group comprised 93 patients with COPD (mean age 65.8 years). The control group comprised 43 systemically healthy individuals (mean age 62.1 years). Respiratory and periodontal conditions were examined in both groups. COPB subjects had significantly worse periodontal conditions than controls (p<0.05) with regard to each parameter of periodontal condition, except for gingival inflammation. COPD patients had higher Plaque Index than control patients (82.84±22.81 vs. 57.15±26.96; p<0.001), higher periodontal depth (3.02±0.92 vs. 2.57±0.79 mm; p=0.007), higher gingival recession (1.97±1.09 vs. 0.91±0.79 mm; p<0.001), and higher mean clinical attachment loss (CAL) (4.12±1.74 vs. 2.91±1.27 mm; p<0.001). Multiple logistic regression model, after controlling for other risk indicators, showed that periodontal disease, presented as CAL ≥4mm at ≥60% sites, was associated with odds ratio of 3.2 (95% CI 1.0-9.8) for the COPB group. Data suggest that periodontal disease could be a risk indicator for COPD.


chronic obstructive pulmonary disease, smoking, periodontitis, clinical attachment loss, case-control study, Croatia

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