Plasma Content of Glucose, C-reactive Protein, Uric Acid and Cholesterol in Male, Female and Ovariectomized Rats upon Acute and Chronic Stress – a Path for Development of Cardiovascular Diseases

Marta Balog, Dražen Mlinarević, Vatroslav Šerić, Milan Miljanović, Robert Blažeković, Ivan Večeslav Degmečić, Senka Blažetić, Ivana Oršolić, Sandor G. Vari, Marija Heffer


 A B S T R A C T

            To explore sex differences in cardiovascular function under stress, we analyzed plasma levels of glucose, C-reactive protein (CRP), uric acid and cholesterol in male, female and ovariectomized rats under acute and chronic stress. Glucose tolerance test (GTT) was performed in all rats before any stress was performed, as well as later in the chronic stress experiment. GTT in control animals showed the same trend as in chronically stressed. Male rats showed the highest plasma level of glucose and uric acid upon acute stress in comparison between the other two groups. Ovariectomized rats reached the highest concentration of plasma cholesterol during acute and chronic stress, respectively and also the highest plasma concentration of CRP during acute stress. Stress, as a risk factor of metabolic syndrome, affected biochemical parameters in males upon acute more than upon chronic stress, but the opposite was observed in female rats. Gender differences supported by ovariectomy show that stress managing could be affected by sexual hormones.


cardiovascular diseases, chronic stress, acute stress, cholesterol, glucose, uric acid, C-reactive protein, ovariectomy, estrogens, plasma

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