Alzheimer and Lewy body Pathology or Creutzfeldt-Jakob Disease

Ana Krvavica, Miro Morović, Anamarija Mrđen, Damir Mišlov, Klaudia Duka-Glavor, Krešimir Ivanac, Ellen Gelpi

Abstract


Objective:  To describe the neuropathological findings of a patient clinically presenting with rapidly progressive nonspecific neurological symptoms suggestive of Creutzfeldt-Jakob disease.

Methods:  Clinical  description  with  laboratory analyses, repeated electroencephalogram, cerebral computed tomography, magnetic resonance imaging studies  and  details on neuropathological work-up.

Results: Neuropathological examination excluded Creutzfeldt-Jakob disease.By contrast other neurodegenerative changes  combining  Alzheimer-type pathology and Lewy body pathology were detected as the most likely substrate of neurological symptoms.

Conclusion: Dementia with Lewy bodies  should  be included  in  the differential diagnosis in  individuals  presenting  with  rapidly progressive  dementia.

Keywords*


dementia, Lewy body, Alzheimer disease, Parkinson disease, Creutzfeldt-Jakob disease

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