The Influence of Allogeneic Platelet Gel on the Morphology of Human Long Bones

Borut Gubina, Primož Rožman, Mirza Bišćević, Dragoslav Domanović, Dragica Smrke

Abstract


The aim of this study is to analyze the morphologic and functional change of human bone defect after its grafting with mixture of platelet gel and autologous cancellous bone. For one year, we have prospectively studied nine consecutive patients, aged 25-73 y., with pseudoarthrosis of long bones, after unsuccessful initial surgeries. We have harvested cancellous bone from patients’ iliac crests and mixed with the ABO compatible allogeneic platelet rich plasma (PRP) gel. That mixture has been inserted in the bone defect, and surgically fixated. Radiologically, the defects achieved the bone morphology (the appearance of hazy callus) between 6th and 24th week. The time of functional recovery was varied, between 12 and 40 weeks for partial weight bearing, and between 16 and 48 weeks for free limb mobility and full function of the limb. The overall healing of bone defect was 16 to 36 weeks. Two patients had complications of poor graft ingrowth and one with a reversible postsurgical nerve paresis. On the X ray scans, solid and fast restoration of bone structure was notable, with excellent bone ingrowth, suitable for full weight bearing. The allogeneic platelet gel had no adverse effects. This method can be used for treating of long bone defects, because of its strong influence on restoration of normal bone morphology. Further investigation is required to establish efficiency relative to other methods. 


Keywords*


platelets; bone transplantation; trauma; plasma; bone grafting; morphology

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